7–12 May 2023
Venice, Italy
Europe/Zurich timezone

An beam line setup for flash radiation therapy with focused electron beams at the Pitz facility at DESY in Zeuthen: basic concept and dosimetry simulations

THPM050
11 May 2023, 16:30
2h
Sala Mosaici 2

Sala Mosaici 2

Poster Presentation MC8.U01: Medical Applications Thursday Poster Session

Speaker

Zohrab Amirkhanyan (Center for the Advancement of Natural Discoveries using Light Emission)

Description

The aim of this work is to demonstrate the principal possibility to enhance the electron beam dose deposition in the depth of the sample for radiation therapy purposes. Trains of electron bunches of 22 MeV generated at PITZ are focused inside the sample using a dedicated fast deflector and a solenoid magnet. To explore the capabilities of the proposed setup, dose distributions are calculated for multiple electron bunches focused in a single point inside a water phantom. Electron beam focusing produces dose peaks with a tunable maximal dose depth which is interesting for healthy tissue sparing at the surface and enhancing treatment quality. The duration of the full bunch train is 1 ms. During this time interval, the FLASH effect could be efficiently triggered inside the irradiated target volume. Monte Carlo simulations based on the FLUKA code were performed to evaluate the depth dose curves distributions in a water phantom. Using the PITZ electron beam parameters, simulations have shown the possibility to produce a peak dose in water seven times higher than compared to the dose at the surface. Moreover, the RMS size homogeneous area around the maximal dose is approximately 25 mm.

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Author

Zohrab Amirkhanyan (Center for the Advancement of Natural Discoveries using Light Emission)

Co-authors

Anne Oppelt (Deutsches Elektronen-Synchrotron DESY) Dr Houjun Qian (DESY) Matthias Gross (Deutsches Elektronen-Synchrotron DESY) Mikhail Krasilnikov (Deutsches Elektronen-Synchrotron DESY) Xiangkun Li (Deutsches Elektronen-Synchrotron DESY) Zakaria Aboulbanine (Deutsches Elektronen-Synchrotron DESY) Felix Riemer (Deutsches Elektronen-Synchrotron DESY) Sebastian Philipp (Deutsches Elektronen-Synchrotron DESY) Thorsten Kuhl (Deutsches Elektronen-Synchrotron DESY) Frank Stephan (Deutsches Elektronen-Synchrotron DESY) Anna Grebinyk (Technical University of Applied Sciences Wildau) Vitali Khachatryan (Center for the Advancement of Natural Discoveries using Light Emission)

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