Speaker
Description
FLASH radiotherapy is emerging as a transformative cancer-treatment modality, achieving tumor control while reducing normal-tissue toxicity and improving the therapeutic index. To exploit this effect, especially for deep-seated tumors, Very High-Energy Electrons (VHEE) in the 50–150 MeV range are required. Within the SAFEST project, aimed at a 100 MeV machine, Sapienza University of Rome, with INFN, is developing a compact C-band linear accelerator prototype. The system is designed to deliver 24 MeV loaded electrons, providing 2 Gy per pulse over a 10 × 10 cm² field at 100 Hz. Accelerator optimization included electromagnetic, vacuum and beam-dynamics studies to ensure beam parameters suitable for FLASH dose delivery. To reach high gradients and enable future VHEE operation in a compact footprint, the work focuses on the in-house design and construction of a C-band travelling-wave structure. The final technical design report is complete, and installation is underway at Sapienza University. Two irradiation configurations, pencil beam and wide beam, are planned for in vitro studies. This compact electron source is a milestone toward next-generation VHEE facilities for FLASH therapy.
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