Speaker
Description
Actinium-225 is a radionuclide of significant interest in the field of Targeted Alpha Particle Radiotherapy (TAT), with its targeted drugs showing promising applications for prostate cancer, brain tumours, neuroendocrine tumours, and more. One of the primary approaches being explored by major international laboratories for the commercial production of $^{225}\text{Ac}$ involves the spallation reaction induced by high-energy proton accelerators (>70 MeV) irradiating a $^{232}\text{Th}$ target. This study conducted detailed simulations using the Monte Carlo program FLUKA to analyze the production yield of $^{225}\text{Ac}$, reaction products, variations in impurity radionuclide yields with cooling time, and the $^{227}\text{Ac}$/$^{225}\text{Ac}$ ratio at different energies in the context of irradiating a thorium target with the 100 MeV proton cyclotron at the China institute of atomic energy(CIAE) in China. The findings provide a reference for subsequent engineering experiments on producing $^{225}\text{Ac}$ via irradiation of thorium targets with medium and high-energy proton accelerators.CIAE conducted irradiation experiments on metallic thorium targets using the 100 MeV cyclotron, achieving an experimental production yield of 0.02 mCi/μAh.
