Speaker
Description
This study describes the production of $^{68}\text{Ga}$ by irradiating an enriched $^{68}\text{ZnCl}_2$ liquid target with a 12 MeV, 50 μA proton beam in a cyclotron. The post-irradiation products were first simulated, and a simulated solution was prepared based on the computational results.
This solution was adjusted to approximately pH 5.0 and subsequently loaded onto a pre-conditioned ZR resin. The subsequent purification involved a two-step process on the ZR resin: first, washing with HCl (pH = 4) effectively removed 99.99% of the ⁶⁸Zn substrate; second, ⁶⁸Ga was efficiently eluted using 5 mol/L HCl.
The resulting $^{68}\text{Ga}$-containing eluate was then loaded onto a pre-conditioned anion exchange resin for further purification. Residual impurity ions were removed by washing the resin with 5 mol/L HCl, followed by the elution of purified $^{68}\text{Ga}$ using ultrapure water. The chemical purity of the final $^{68}\text{Ga}$ sample was confirmed to comply with the quality specifications for accelerator-produced $^{68}\text{Ga}$ as defined in the European Pharmacopoeia.
