Speaker
Description
The CERN Linear Electron Accelerator for Research (CLEAR) provides versatile electron beams for multidisciplinary studies, including advanced research on Very High Energy Electrons (VHEE, 100–200 MeV) at Ultra-High Dose Rates (UHDR >10⁸ Gy/s) for radiotherapy in the FLASH regime, in which normal tissue toxicity is reduced when the dose is delivered within milliseconds. Leveraging CLEAR’s adjustable beam time structure, recent experiments explored how short-timescale beam parameters (down to the picosecond level) influence physico-chemical and biological responses. Such studies were carried out in collaboration with radiobiology groups, particularly at the Hôpitaux Universitaires de Genève mainly using zebrafish embryos. Results indicate that beam intensity and bunch structure strongly affect biological outcomes. Notably, zebrafish morphogenesis can be preserved at instantaneous dose rates near 10¹¹ Gy/s, even when total dose delivery extends to minutes, at average dose rates well below what was so far considered the FLASH threshold. These results highlight CLEAR as a unique platform for defining beam conditions relevant to the FLASH effect in view of future clinical systems.
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