Speaker
Description
FLASH proton therapy has shown the potential to reduce normal-tissue toxicity while maintaining tumor control by delivering radiation in ultra-high dose-rate pulses (>40 Gy/s). However, more radiobiology experiments are needed to better understand the subjacent mechanism and optimize its application beam parameters. To explore this regime using the Cyclotron at Centro Nacionalicémoste de Aceleradores in Seville, we
have developed a fast electrostatic chopper for length beam structure manipulation in order to be able to produce short (~1 um) and high intensity pulsed beams. In this paper, we present the design and optimization of this device, intended to generate well- defined beam pulses for radiobiology experiments in the FLASH regime. Electromagnetic
simulations were performed with CST Particle Studio to define the electrode geometry, determine the required operating voltage, and carry out tolerance studies for the mechanical design. The designed chopper was integrated into a full TOPAS model of the external cyclotron beamline to evaluate the need of additional subsystems such as a
collimator and to optimize the operational parameters. First studies carried out with this model are also presented.
| In which format do you inted to submit your paper? | LaTeX |
|---|