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The use of mixed ion beams is a developing approach aimed at improving current carbon-ion therapy by enabling online monitoring of dose deposition. In such a configuration, the main dose is still delivered by carbon ions, while lighter ions traverse the patient with negligible dose contribution and can be used for imaging. The main challenges of this approach include the need to simultaneously accelerate both ion species and to slowly extract them with a stable species ratio, a prerequisite for potential clinical application. At GSI, a mixed beam of 12C3+ and 4He+ ions was provided in May 2025 for biophysics experiments. The very small mass-to-charge difference of 0.065 % between these ion species enables simultaneous acceleration in the SIS18 heavy-ion synchrotron. To slowly extract them with transverse RF-knockout, chromaticity in the ring was adjusted, and the spill optimization system was used. These measures enabled a nearly rectangular spill with a constant helium/carbon ratio within the spill, confirmed by ionization-chamber measurements in the medical cave. This contribution presents the experimental results and discusses their implications for mixed-beam operation.
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