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Description
Ac-225 is a crucial isotope for targeted alpha therapy, yet its clinical application is severely constrained by supply shortages. The use of high-intensity proton beams to irradiate Ra-226 targets offers a viable approach to significantly enhance Ac-225 production, as it enables higher yields and greater scalability. However, the process is also accompanied by the generation of other isotopes of actinium, especially the long-lived Ac-227, which challenges the purification process. This work establishes a precise parameterized model that correlates beam energy, target thickness, and cooling time with each other for optimizing Ac-225 production while minimizing Ac-227 impurity levels and target material consumption. We determine the optimal parameters, which effectively maximize Ac-225 yield while controlling impurity levels and target material consumption. This method provides a valuable reference for the efficient production of Ac-225
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