Speaker
Description
Ac-225 is a crucial isotope for targeted alpha therapy, yet its clinical application is severely constrained by supply shortages. The use of high-intensity proton beams from linear accelerators to irradiate Ra-226 targets offers a viable approach to significantly enhance Ac-225 production. However, excessive proton energies, while increasing yield, promote the generation of impurity isotopes such as Ac-227, complicating chemical separation and raising both production costs and radiological concerns.This study employs Geant4 Monte Carlo simulations with a detailed model that includes the beam window, target, and encapsulation structure. By systematically simulating nuclear reactions across various energy levels, we quantified the production yields of Ac-225 and its impurities. An optimal proton energy was identified that maximizes Ac-225 yield while effectively controlling impurity levels, providing key insights for efficient large-scale Ac-225 production.
| In which format do you inted to submit your paper? | LaTeX |
|---|---|
| Preprint marking on your proceeding paper | I wish my paper to be marked as preprint. |