May 7 – 12, 2023
Venice, Italy
Europe/Zurich timezone

Three-Stage Simulation for the Development of an Ion-Acoustic Dose-Deposition Mapping System for LhARA

SUPM030
May 7, 2023, 2:00 PM
4h
Sala Mosaici 2

Sala Mosaici 2

Poster Presentation Student Poster Session

Speaker

Maria Maxouti (Imperial College London)

Description

LhARA, the Laser-hybrid Accelerator for Radiobiological Applications, is a proposed facility for the study of proton and ion radiation biology. The accelerator is designed to deliver a variety of ion species over a wide range of spatial and temporal profiles at ultra-high dose rates. The facility requires that the deposited dose distribution be measured in real-time. For this purpose, an ion-acoustic dose mapping system has been developed that, exploits the ultrasound waves generated by the ion beam*. The feasibility of this approach is being evaluated using a two-stage simulation.
A water phantom modelled in Geant4 with beam energies up to 250 MeV is used to calculate the energy deposited by the beam as a function of position and time. The time-dependent 3D energy distribution is then used as the source in k-Wave to simulate the ion energy generation of acoustic (pressure) waves and their propagation in the three-dimensional space. A hemispherical acoustic sensor array is also simulated and its ability to reconstruct the generated pressure distribution is evaluated.
The results show that the 3D deposited-energy distribution can be reconstructed with sub-millimetre accuracy and suggest, that further development of the system can lead to real-time, non-invasive Bragg peak localization and dose deposition profile measurement during ion-beam therapy.

Footnotes

  • Aymar G. et al. Front Phys. 2020;0:432.
    ** Haffa D. et al. Sci Rep. 2019;9(1):6714.
    *** Allison J. et al. Nucl. Instrum. Meth. A. 2016;835:186-225.
    **** Treeby BE, Cox BT. J. Biomed. Opt. 2010;15(2):021314.

Funding Agency

Science and Technology Facilities Council (STFC)

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Primary author

Maria Maxouti (Imperial College London)

Co-authors

Hin Tung Lau (Imperial College London) Josie McGarrigle (Imperial College London) Anthea MacIntosh-LaRocque (Imperial College of Science and Technology) Emma Harris (The Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust) Colin Whyte (University of Strathclyde) John Matheson (Science and Technology Facilities Council) Jeffrey Bamber (The Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust) Ben Cox (Department of Medical Physics and Biomedical Engineering) Kenneth Long (Imperial College of Science and Technology)

Presentation materials

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