10–15 Aug 2025
SAFE Credit Union Convention Center
America/Los_Angeles timezone

High-Precision Characterization of MeV Electron Interactions for Advanced Nano-Imaging of Thick Biological Samples and Microchips

FRAN02
15 Aug 2025, 09:50
20m
Parallel Session #2 (SAFE Credit Union Convention Center)

Parallel Session #2

SAFE Credit Union Convention Center

Contributed Oral Presentation MC8 – Applications of Accelerators, Technology Transfer, Industrial Relations, and Outreach Applications of Accelerators, Technology Transfer, Industrial Relations, and Outreach (Contributed)

Speaker

Xi Yang (Brookhaven National Laboratory)

Description

The resolution of a MeV Scanning Transmission Electron Microscope (MeV-STEM) is mainly limited by the electron beam properties and angular broadening in thick biological samples and microchips. Addressing these challenges requires understanding beam emittance, optical aberrations, and energy-dependent scattering angles. We propose a standardized method to assess beam intensity, divergence, and size at the sample exit to better characterize electron-sample interactions, align analytical models, and validate Monte Carlo simulations. Our results show that accurately measuring parameters—especially angular broadening—is both feasible and essential for improving resolution. Using a high-energy (1–10 MeV) electron source and tailored beams, along with amorphous ice and silicon as sample proxies, we aim to optimize beam energy and focus for enhanced imaging. This is critical for in-situ imaging of thick biological samples and detecting nanometer-scale microchip defects. Ultimately, we aim to map the minimum electron energy needed for nanoscale resolution across varying sample types and imaging modes.

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Author

Xi Yang (Brookhaven National Laboratory)

Co-authors

Victor Smaluk (National Synchrotron Light Source II) Timur Shaftan (Brookhaven National Laboratory) Dr Tianyi Wang (National Synchrotron Light Source II) Dr Nathalie Bouet (National Synchrotron Light Source II) Pietro Musumeci (University of California, Los Angeles) Dr Gabriele D’Amen (Brookhaven National Laboratory) Dr Liguo Wang (Brookhaven National Laboratory)

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